7 months ago

221

Another diabetes drug, this time from the UK, is being heralded as a wonder drug if prescribed off label, that could be the answer to weight loss.
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Links:
https://www.sciencealert.com/diabetes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020673/
https://www.nejm.org/doi/full/10.1056/NEJMoa2107519
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02188-7/fulltext
https://www.nature.com/articles/s42255-019-0146-4_
https://shorturl.ac/7byvv
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9758543/
https://www.ema.europa.eu/en/medicines/human/EPAR/mounjaro
https://shorturl.ac/7byw0
https://www.nice.org.uk/guidance/indevelopment/gid-ta10835
https://theconversation.com/ozempic-shortages-in-the-uk-may-last-until-2024-heres-why-208819
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632188/
https://onlinelibrary.wiley.com/doi/full/10.1002/oby.21107
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)33102-1/fulltext
https://shorturl.ac/7byvw
https://shorturl.ac/7byvy
https://www.nejm.org/doi/full/10.1056/NEJMoa2206038
https://shorturl.ac/7byvz
https://www.nice.org.uk/guidance/gid-ta10835/documents/674
https://www.diabetes.org.uk/about_us/news/mounjaro-approved-nice-treating-type-2-diabetes
https://www.annualreviews.org/doi/abs/10.1146/annurev-nutr-062320-113625

This new drug that was developed to treat type 2 diabetes has been approved for use in the UK. Tirzepatide (to be sold under the brand name Mounjaro) could be available for prescription by early 2024, that all being subject to its availability. Mounjaro is an injectable treatment that helps the body to both control blood glucose (that’s sugars) after meals and also to regulate appetite. Research into the drug has shown it's more effective in controlling blood sugar and leads to greater weight loss when it is compared with the type 2 diabetes drugs currently available for prescription. Tirzepatide is derived from a protein with a similar structure to the hormone GIP (glucose-dependent insulinotropic peptide), which stimulates the release of insulin. But what's unique about tirzepatide is that it binds to the receptors of another hormone called GLP-1 (glucagon-like peptide 1), which also releases insulin. This makes tirzepatide the first "dual-hormone agonist" to be approved for treating type 2 diabetes. A “dual-hormone agonist” is a drug which binds to a hormone's receptor and then activates it). Semaglutide, which is sold under the brand name Ozempic, only targets GLP-1. So, how does this new drug work, how does it differ to other diabetes drugs? The hormones GLP-1 and GIP are produced by specialized cells in our large and small intestines, which release them in response to rising levels of blood glucose after a meal. Ozempic, Mounjaro, Semaglutide
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#Ozempic #Mounjaro #Semaglutide

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