Tuckergoodrich

Introduction I am honored to be joined by John Speakman, a leading authority on energy balance in animals, and in the use of the doubly-labeled water method of determining energy balance. This has led him into the study of obesity, among other topics, where he has become a recognized expert. Our discussion was prompted by his recent paper, “Total Daily Energy Expenditure Has Declined Over the Past Three Decades Due to Declining Basal Expenditure, Not Reduced Activity Expenditure”, which casts a new light onto the world pandemic of obesity. In addition to discussing a few of the papers that give some background to that one, and his future research plans in light of that paper, we have an enlightening discussion on the potential role of deuterium in obesity and chronic disease. Biography: “John Roger Speakman (born 1958) FRS FRSE FRSB FRSA FMedSci FRSS is a British biologist working at the University of Aberdeen, Institute of Biological and Environmental Sciences, for which he was Director from 2007 to 2011. He leads the University's Energetics Research Group, which is one of the world's leading groups using doubly labeled water (DLW) to investigate energy expenditure and balance in animals. Between 2011-2020, he was a '1000 talents' Professor at the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, in Beijing, China, where he ran the molecular energetics group. In 2020 he moved to the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences in Shenzhen, China where he works at the Center for Energy Metabolism and Reproduction and Head of the Shenzhen Key laboratory of Metabolic Health.” https://en.wikipedia.org/wiki/John_Speakman _______________________________________ Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/ Tucker Goodrich Substack: https://tuckergoodrich.substack.com/ Twitter: https://twitter.com/TuckerGoodrich Youtube: https://www.youtube.com/tuckergoodrich0 Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825 Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y Podcast: https://sites.libsyn.com/408758 Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/ _______________________________________ Show Notes Hu, S., Wang, L., Yang, D., Li, L., Togo, J., Wu, Y., Liu, Q., Li, B., Li, M., Wang, G., Zhang, X., Niu, C., Li, J., Xu, Y., Couper, E., Whittington-Davies, A., Mazidi, M., Luo, L., Wang, S., … Speakman, J. R. (2018). Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice. Cell Metabolism, 28(3), 415-431.e4. https://doi.org/10.1016/j.cmet.2018.06.010 Wu, Y., Li, B., Li, L., Mitchell, S. E., Green, C. L., D’Agostino, G., Wang, G., Wang, L., Li, M., Li, J., Niu, C., Jin, Z., Wang, A., Zheng, Y., Douglas, A., & Speakman, J. R. (2021). Very-Low-Protein Diets Lead to Reduced Food Intake and Weight Loss, Linked to Inhibition of Hypothalamic Mtor Signaling, in Mice. Cell Metabolism, 33(6), 1264–1266. https://doi.org/10.1016/j.cmet.2021.04.016 McNay, D. E. G., & Speakman, J. R. (2013). High Fat Diet Causes Rebound Weight Gain. Molecular Metabolism, 2(2), 103–108. https://doi.org/10.1016/j.molmet.2012.10.003 Speakman, J. R., De Jong, J. M. A., Sinha, S., Westerterp, K. R., Yamada, Y., Sagayama, H., Ainslie, P. N., Anderson, L. J., Arab, L., Bedu-Addo, K., Blanc, S., Bonomi, A. G., Bovet, P., Brage, S., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Cooper, J. A., Cooper, R., … Wong, W. W. (2023). Total Daily Energy Expenditure Has Declined Over the Past Three Decades Due to Declining Basal Expenditure, Not Reduced Activity Expenditure. Nature Metabolism, 5(4), 579–588. https://doi.org/10.1038/s42255-023-00782-2 Gurven, M., Kraft, T. S., Alami, S., Adrian, J. C., Linares, E. C., Cummings, D., Rodriguez, D. E., Hooper, P. L., Jaeggi, A. V., Gutierrez, R. Q., Suarez, I. M., Seabright, E., Kaplan, H., Stieglitz, J., & Trumble, B. (n.d.). Rapidly Declining Body Temperature in a Tropical Human Population. Science Advances, 6(44), eabc6599. https://doi.org/10.1126/sciadv.abc6599 Protsiv, M., Ley, C., Lankester, J., Hastie, T., & Parsonnet, J. (2020). Decreasing Human Body Temperature in the United States Since the Industrial Revolution. eLife, 9, e49555. https://doi.org/10.7554/eLife.49555 Linares, C., & Su, D. (2005). Body Mass Index and Health Among Union Army Veterans: 1891–1905. Economics & Human Biology, 3(3), 367–387. https://doi.org/10.1016/j.ehb.2005.06.002 Sørensen, T. I. A., Martinez, A. R., & Jørgensen, T. S. H. (2022). Epidemiology of Obesity. In J. Eckel & K. Clément (Eds.), From Obesity to Diabetes (pp. 3–27). Springer International Publishing. https://doi.org/10.1007/164_2022_581 Schramm, S., Sørensen, T. I. A., Davidsen, M., & Tolstrup, J. S. (2023). Changes in Adult Obesity Prevalence in Denmark, 1987–2021: Age–Period–Cohort Analysis of Nationally Representative Data. European Journal of Public Health, 33(3), 463–467. https://doi.org/10.1093/eurpub/ckad024 Haggerty, C., Hoggard, N., Brown, D. S., Clapham, J. C., & Speakman, J. R. (2008). Intra-Specific Variation in Resting Metabolic Rate in Mf1 Mice Is Not Associated with Membrane Lipid Desaturation in the Liver. Mechanisms of Ageing and Development, 129(3), 129–137. https://doi.org/10.1016/j.mad.2007.11.001 Zhang, L.-N., Gamo, Y., Sinclair, R., Mitchell, S. E., Morgan, D. G., Clapham, J. C., & Speakman, J. R. (2012). Effects of Chronic Oral Rimonabant Administration on Energy Budgets of Diet-Induced Obese C57BL/6 Mice. Obesity, 20(5), 954–962. https://doi.org/10.1038/oby.2011.357 “There were four suicides in the rimonabant group (0·07%) and one in the placebo group (0·02%). The number of deaths for bariatric surgery, a widely used alternative treatment for severe obesity, would have been expected to be far greater, and in centres of excellence has been reported to be 0·3% at 90 days.2” Topol, E. J., Bousser, M.-G., Fox, K. A., & Montelescot, G. (2010). Termination of the CRESCENDO trial – Authors’ reply. The Lancet, 376(9757), 1984–1985. https://doi.org/10.1016/S0140-6736(10)62256-8 Else, P. L., & Hulbert, A. J. (1987). Evolution of Mammalian Endothermic Metabolism: “Leaky” Membranes as a Source of Heat. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 253(1), R1–R7. https://doi.org/10.1152/ajpregu.1987.253.1.R1 Speakman, J. R., Sørensen, T. I. A., Hall, K. D., & Allison, D. B. (2023). Unanswered Questions About the Causes of Obesity. Science, 381(6661), 944–946. https://doi.org/10.1126/science.adg2718 Deuterium Boros, L., Collins, Q., & Somlyai, G. (2018, September 24). Deuterium and Metabolic Water Matter – What This Means Biochemically and Clinically. https://www.science.org/doi/10.1126/sciadv.aat7314#elettersSection If you have any questions about sources for things discussed please ask in the comments.

Introduction Cancer is the second-leading killer of Americans, and is increasing both around the world and increasingly affecting younger and younger people. It’s obviously important to understand what environmental factors might affect our susceptibility to the various cancers. Here we discuss what I think is a key paper showing a link between our environment, genetic mutation, and metabolic dysfunction in cancer cells. “The Major Lipid Peroxidation Product, Trans- 4-Hydroxy-2-Nonenal, Preferentially Forms DNA Adducts at Codon 249 of Human P53 Gene, a Unique Mutational Hotspot in Hepatocellular Carcinoma” (Hu et al., 2002) Guest info Matt Quinn https://twitter.com/Mqsley https://www.mquinn.online/ Biography: TL;DR Here's what I am working on: I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here I have failed at so so so many things - read about them here https://www.mquinn.online/ _______________________________________ Co-host Dr. Brian Kerley https://www.seedoilrebellion.com/ https://twitter.com/SeedOilDsrspctr Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/ Tucker Goodrich Substack: https://tuckergoodrich.substack.com/ Twitter: https://twitter.com/TuckerGoodrich Youtube: https://www.youtube.com/tuckergoodrich0 Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825 Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y Podcast: https://sites.libsyn.com/408758 Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/ _______________________________________ Show Notes Hu, W., Feng, Z., Eveleigh, J., Iyer, G., Pan, J., Amin, S., Chung, F.-L., & Tang, M. (2002). The Major Lipid Peroxidation Product, Trans- 4-Hydroxy-2-Nonenal, Preferentially Forms DNA Adducts at Codon 249 of Human P53 Gene, a Unique Mutational Hotspot in Hepatocellular Carcinoma. Carcinogenesis, 23(11), 1781–1789. https://doi.org/10.1093/carcin/23.11.1781 Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection https://amzn.to/3Unn39b Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer https://amzn.to/44pbz9C Goodrich, T. D. (2021, July 8). Interview: Thomas Seyfried on Glioblastoma, Metabolic Cancer Breakthroughs, with David Gornoski on A Neighbor’s Choice [Blog]. Yelling Stop. https://yelling-stop.blogspot.com/2021/07/podcast-interview-thomas-seyfried-with.html Soussi, T. (2000). The P53 Tumor Suppressor Gene: From Molecular Biology to Clinical Investigation. Annals of the New York Academy of Sciences, 910, 121–137; discussion 137-139. https://doi.org/10.1111/j.1749-6632.2000.tb06705.x Matoba, S., Kang, J.-G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P. J., Bunz, F., & Hwang, P. M. (2006). P53 Regulates Mitochondrial Respiration. Science, 312(5780), 1650–1653. https://doi.org/10.1126/science.1126863 The American Oil Chemists’ Society. (2004, June). Wilhelm Normann (1870-1939). INFORM Magazine. https://lipidlibrary.aocs.org/resource-material/the-history-of-lipid-science-and-technology/wilhelm-normann-(1870-1939) Goodrich, T. D. (2016, January 14). Thyroid and Low-Carb: What Do Thyroid Hormones Do? [Blog]. Yelling Stop. https://open.substack.com/pub/tuckergoodrich/p/thyroid-and-low-carb-what-do-thyroid If you have any questions about sources for things discussed please ask in the comments.

Introduction Dr. Brian Kerley, my co-host (although not on this episode) requested that I break out the seed oil discussion that Jacob and I had in episode 19. I had been thinking this would be a good idea as well, as it was a bit out of place in that episode, although I am glad Jacob wanted to discuss it. So if you have already listened to ep. 19, this will be redundant. We’ll have a new episode out soon. If you haven’t listened to ep. 19, then this was a discussion that Jacob requested we have about some weaknesses that he perceived in the idea that seed oils are causal in chronic disease. Unfortunately, we only touched the tip of the iceberg, but he brought up a number of excellent points, which are well worth discussing. Enjoy! Guest info Jacob Hands, MD candidate and consultant for Consumer Lab on quality control and testing of supplements, and consultant to Rhonda Patrick, MD, of Found my Fitness. Consumer Lab https://www.consumerlab.com/ Found my Fitness https://www.foundmyfitness.com/ Biography: “Medical student passionate about patient care, research, and emerging therapeutics. “M.D. Candidate at The George Washington University School of Medicine and Health Sciences.” https://www.linkedin.com/in/jacob-hands-3622619b/ _______________________________________ Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/ Tucker Goodrich Substack: https://tuckergoodrich.substack.com/ Twitter: https://twitter.com/TuckerGoodrich Youtube: https://www.youtube.com/tuckergoodrich0 Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825 Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y Podcast: https://sites.libsyn.com/408758 Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/ _______________________________________ Show Notes See the notes in the previous episode: https://tuckergoodrich.substack.com/p/ep-19-jacob-m-handswhats-wrong-with

See Substack for more! https://open.substack.com/pub/tuckergoodrich/p/ep-19-jacob-m-handswhats-wrong-with?r=1g2jpl&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Introduction What about fish oil? Is it a problem due to oxidation and contamination? Is it beneficial to health as many claim or is it a PUFA that’s bad for your health? Jacob recently published an analysis of various fish oils with the team at Consumer Labs, looking at oxidative toxicity and purity of a wide variety of commercially available fish oils. We discuss omega-3 and health, fish oils and oxidation, the science of seed oils and health, and, as a bonus, the problem with chocolates. This is definitely a bit of a geek fest, so let me know if you have any questions. Guest info Jacob Hands, MD candidate and consultant for Consumer Lab on quality control and testing of supplements, and consultant to Rhonda Patrick, MD, of Found my Fitness. Consumer Lab https://www.consumerlab.com/ Found my Fitness https://www.foundmyfitness.com/ Biography: “Medical student passionate about patient care, research, and emerging therapeutics. “M.D. Candidate at The George Washington University School of Medicine and Health Sciences.” https://www.linkedin.com/in/jacob-hands-3622619b/ _______________________________________ Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/ Tucker Goodrich Substack: https://tuckergoodrich.substack.com/ Twitter: https://twitter.com/TuckerGoodrich Youtube: https://www.youtube.com/tuckergoodrich0 Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825 Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y Podcast: https://sites.libsyn.com/408758 Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/ _______________________________________ Show Notes Hands, J. M., Anderson, M. L., Cooperman, T., & Frame, L. A. (2023). A Multi-Year Rancidity Analysis of 72 Marine and Microalgal Oil Omega-3 Supplements. Journal of Dietary Supplements, 0(0), 1–12. https://doi.org/10.1080/19390211.2023.2252064 This is the only human study I’m aware of showing harm from eating marine foods. The Japanese and the Eskimos do not suffer from infertility, so I think this gentleman must have been doing something wrong. “I lived for 100 days on nothing but marine animal food (seal, fish, crustaceans and molluscs) and water; weights of all food were recorded….” “In seminal fluid, the total amount of prostaglandins decreased significantly and small amounts of the [Ω-]3-series appeared; spermatozoa became immobile and then disappeared.” Sinclair, H. M. (1981). The Relative Importance of Essential Fatty Acids of the Linoleic and Linolenic Families: Studies with an Eskimo Diet. Progress in Lipid Research, 20, 897–899. https://doi.org/10.1016/0163-7827(81)90167-3 Goodrich, T. D. (2022, April 13). The Folate Experiment [Blog]. Yelling Stop. https://open.substack.com/pub/tuckergoodrich/p/the-folate-experiment Goodrich, T. (2021, October 19). What Is The Most Fattening Food? [Blog]. Yelling Stop. https://tuckergoodrich.substack.com/p/what-is-the-most-fattening-food Mozaffarian, D., Hao, T., Rimm, E. B., Willett, W. C., & Hu, F. B. (2011). Changes in Diet and Lifestyle and Long-Term Weight Gain in Women and Men. New England Journal of Medicine, 364(25), 2392–2404. https://doi.org/10.1056/NEJMoa1014296 Zong, G., Liu, G., Willett, W. C., Wanders, A. J., Alssema, M., Zock, P. L., Hu, F. B., & Sun, Q. (2019). Associations Between Linoleic Acid Intake and Incident Type 2 Diabetes Among U.S. Men and Women. Diabetes Care, 42(8), 1406–1413. https://doi.org/10.2337/dc19-0412 Johns, D. M. (2023, April 13). Nutrition Science’s Most Preposterous Result: Could Ice Cream Possibly Be Good for You? The Atlantic, 5/2023. https://www.theatlantic.com/magazine/archive/2023/05/ice-cream-bad-for-you-health-study/673487/ Pearce, N. (2011). Epidemiology in a Changing World: Variation, Causation and Ubiquitous Risk Factors. International Journal of Epidemiology, 40(2), 503–512. https://doi.org/10.1093/ije/dyq257 Huang, Z., Sun, S., Lee, M., Maslov, A. Y., Shi, M., Waldman, S., Marsh, A., Siddiqui, T., Dong, X., Peter, Y., Sadoughi, A., Shah, C., Ye, K., Spivack, S. D., & Vijg, J. (2022). Single-Cell Analysis of Somatic Mutations in Human Bronchial Epithelial Cells in Relation to Aging and Smoking. Nature Genetics, 54(4), Article 4. https://doi.org/10.1038/s41588-022-01035-w Jacob’s Discussion Notes See Substack: https://open.substack.com/pub/tuckergoodrich/p/ep-19-jacob-m-handswhats-wrong-with?r=1g2jpl&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true If you have any questions about sources for things discussed please ask in the comments.

Diabetes, broadly defined, afflicts greater than 50% of the U.S. population. The hallmark of type 2 diabetes is insulin resistance. While many are unable to answer the question of why a formerly rare disease now afflicts the majority of the population, we go over research dating back to 1964 that makes it clear that we have a pretty good idea of what causes insulin resistance. Scientists can easily induce insulin resistance in humans. How do they do it, and what might it tell us about what has caused our epidemic of diabetes? Guest info Matt Quinn https://twitter.com/Mqsley https://www.mquinn.online/ Biography: TL;DR Here's what I am working on: I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here I have failed at so so so many things - read about them here https://www.mquinn.online/ _______________________________________ Co-host Dr. Brian Kerley https://www.seedoilrebellion.com/ https://twitter.com/SeedOilDsrspctr Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/ Tucker Goodrich Substack: https://tuckergoodrich.substack.com/ Twitter: https://twitter.com/TuckerGoodrich Youtube: https://www.youtube.com/tuckergoodrich0 Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825 Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y Podcast: https://sites.libsyn.com/408758 Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/ _______________________________________ Show Notes Felber, J. P., & Vannotti, A. (1964). Effects of Fat Infusion on Glucose Tolerance and Insulin Plasma Levels. Medicina Experimentalis: International Journal of Experimental Medicine, 10, 153–156. https://doi.org/10.1159/000135410 Nowotny, B., Zahiragic, L., Krog, D., Nowotny, P. J., Herder, C., Carstensen, M., Yoshimura, T., Szendroedi, J., Phielix, E., Schadewaldt, P., Schloot, N. C., Shulman, G. I., & Roden, M. (2013). Mechanisms Underlying the Onset of Oral Lipid–Induced Skeletal Muscle Insulin Resistance in Humans. Diabetes, 62(7), 2240–2248. https://doi.org/10.2337/db12-1179 Attia, P. (2020, December 7). #140 - Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implications (140) [Mp3]. https://peterattiamd.com/geraldshulman/ Koch, S., Cohen, D., & Carroll, L.. (2013, June 7). Drug treatment Omegaven that could save infants’ lives not yet approved by FDA [Mp4]. In NBC News. NBC. http://www.nbcnews.com/nightly-news/drug-treatment-omegaven-could-save-infants-lives-not-yet-approved-flna6C10249250 If you have any questions about sources for things discussed please ask in the comments.

Introduction We look at a paper about the process of how the fats in seed oils become toxic, and what effects those toxins can have. This paper is a broad overview of the related disease processes, which we will discuss to further understand how one thing can be driving many different disease processes. “The study of lipid peroxidation (LPO) processes has become a rapidly growing field in medicine and biology, based on increasing evidence that LPO is involved in the development of many chronic diseases, e.g. [references removed] (1) Asthma (2) Atherosclerosis (3) Alzheimer’s disease (4) Rheumatoid arthritis (5) Burn injury (6) Cataractogenesis (7) Diabetes (8) Endotoxin liver injury (9) Multiple sclerosis (10) Myocardial infarction (11) Organ transplantation (12) Parkinson disease (13) Psoriasis (14) Reperfusion injury (15) Stroke (16) Aging “The obvious involvement of LPO processes in the majority of severe diseases stimulated worldwide efforts to elucidate the mechanisms of their generation. “These efforts are expressed in the exploding flood of papers, conference reports, review articles (see above) and books dealing with LPO. This paper is, therefore, not intended to add to these reviews but rather to address aspects previously overlooked: the dominant role of linoleic acid (LA) in LPO and the application of a combination of modern separation and identification techniques to isolate LPO products. Knowledge of these products provides insight into the mechanisms of their generation and offers a better understanding of the diseases in which LPO is involved.” (Spiteller 1998) Guest info Matt Quinn https://twitter.com/Mqsley https://www.mquinn.online/ Biography: TL;DR Here's what I am working on: I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here I have failed at so so so many things - read about them here https://www.mquinn.online/ _______________________________________ Co-host Dr. Brian Kerley https://www.seedoilrebellion.com/ https://twitter.com/SeedOilDsrspctr Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/ Tucker Goodrich Substack: https://tuckergoodrich.substack.com/ Twitter: https://twitter.com/TuckerGoodrich Youtube: https://www.youtube.com/tuckergoodrich0 Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825 Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y Podcast: https://sites.libsyn.com/408758 Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/ _______________________________________ Show Notes Episode 14 Post Script: Matt Has a Surprising Easter Egg https://youtu.be/1D17vUvbHhk Spiteller, G. (1998). Linoleic Acid Peroxidation—The Dominant Lipid Peroxidation Process in Low Density Lipoprotein—And Its Relationship to Chronic Diseases. Chemistry and Physics of Lipids, 95(2), 105–162. https://doi.org/10.1016/S0009-3084(98)00091-7 If you have any questions about sources for things discussed please ask in the comments.

Introduction We are honorored to be joined by Prof. A. J. Hulbert, noted zoologist and author of Omega Balance: Nutritional Power for a Happier, Healthier Life. “In Omega Balance, noted scientist Anthony J. Hulbert explains how the balance between [Omega-3 and omega-6 fatty acids] in the human food chain has changed over the last half-century and the very serious negative health impacts this imbalance has created. An imbalance of these omega fats contributes to increased rates of obesity, diabetes, cardiovascular diseases, allergies, asthma, as well as cancer and a variety of other inflammatory diseases. Omega balance is also important for normal brain function, and an imbalance in these fatty acids is associated with depression, mood disorders, and neurodegenerative diseases. Hulbert provides extensive information on the omega balance of different foods and discusses fascinating details about human evolution, dietary changes throughout history, the effect of diet on human development and physiological processes, and more. He investigates the paleo diet of our ancestors and describes the dramatic changes that have accompanied the increased ultra-processing of modern foods. Omega Balance is an essential guide to understanding a significant problem in our modern food chain and will make us rethink the food we eat. https://press.jhu.edu/books/title/12823/omega-balance Amazon link to benefit this podcast: https://amzn.to/49JHXFo This book won a “Best Book” award from the American Book Fest in the category “Health: Diet and Exercise”. https://www.americanbookfest.com/2023bbafullresults.html Guest info I was introduced to Prof. Hulbert by Prof. Tom Brenna, our guest in Ep. 5: Prof. Tom Brenna, Omega-3 and Omega-6 in Human Health. Biography: “Anthony John Hulbert (UNSW, AUS), PhD, DSc, is an internationally renowned researcher on metabolism, longevity, and nutrition. He is emeritus professor in Science, Medicine, and Health at the University of Wollongong, Australia.” https://press.jhu.edu/books/title/12823/omega-balance#book__authors _______________________________________ Co-host Co-host Dr. Brian Kerley https://www.seedoilrebellion.com/ https://twitter.com/SeedOilDsrspctr Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/ Tucker Goodrich Substack: https://tuckergoodrich.substack.com/ Twitter: https://twitter.com/TuckerGoodrich Youtube: https://www.youtube.com/tuckergoodrich0 Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825 Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y Podcast: https://sites.libsyn.com/408758 Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/ _______________________________________ Show Notes In order of discussion. Borchman, D., Stimmelmayr, R., & George, J. C. (2017). Whales, Lifespan, Phospholipids, and Cataracts. Journal of Lipid Research, 58(12), 2289–2298. https://doi.org/10.1194/jlr.M079368 Hulbert, A. J., & Else, P. L. (1999). Membranes as Possible Pacemakers of Metabolism. Journal of Theoretical Biology, 199(3), 257–274. https://doi.org/10.1006/jtbi.1999.0955 Abbott, S. K., Else, P. L., Atkins, T. A., & Hulbert, A. J. (2012). Fatty Acid Composition of Membrane Bilayers: Importance of Diet Polyunsaturated Fat Balance. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1818(5), 1309–1317. https://doi.org/10.1016/j.bbamem.2012.01.011 McCollum, E. V. (1919). The Newer Knowledge of Nutrition. Macmillan Company. https://ia801302.us.archive.org/28/items/cu31924104225937/cu31924104225937.pdf Speakman, J. R., De Jong, J. M. A., Sinha, S., Westerterp, K. R., Yamada, Y., Sagayama, H., Ainslie, P. N., Anderson, L. J., Arab, L., Bedu-Addo, K., Blanc, S., Bonomi, A. G., Bovet, P., Brage, S., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Cooper, J. A., Cooper, R., … Wong, W. W. (2023). Total Daily Energy Expenditure Has Declined Over the Past Three Decades Due to Declining Basal Expenditure, Not Reduced Activity Expenditure. Nature Metabolism, 5(4), 579–588. https://doi.org/10.1038/s42255-023-00782-2 Allport, S. (2010, November). One Person’s Response to a High Omega-6 Diet [Magazine]. American Oil Chemists’ Society. https://www.aocs.org/stay-informed/inform-magazine/featured-articles/one-persons-response-to-a-high-omega-6-diet-november-2010?SSO=True If you have any questions about sources for things discussed please ask in the comments.

Introduction We look at a paper enlightening what causes chronic disease, in the context of a huge population of people who suffer from the most common human mutation, to the aldehyde dehydrogenase enzyme that detoxifies both alcohol and seed oil metabolites, the ALDH2*2 mutation. We discuss how this mutation is thought to affect the people who have it through the lens of the paper at hand. This was a difficult video for me to edit, as both Matt and Brian share their experiences with the topic we are discussing in their own families. I thought this was excellent, and hope many others can learn from it. Here’s this paper: “A Common East Asian-Specific ALDH2 Mutation Causes Obesity and Insulin Resistance: Therapeutic Effect of Reducing Toxic Aldehydes by ALDH2 Activation” Preprint: Chang, Y.-C., Lee, H.-L., Yang, W., Hsieh, M.-L., Liu, C.-C., Lee, T.-Y., Huang, J.-Y., Nong, J.-Y., Li, F.-A., Chuang, H.-L., Ding, Z.-Z., Su, W.-L., Chueh, L.-Y., Tsai, Y.-T., Chen, C.-H., Mochly-Rosen, D., & Chuang, L.-M. (2020). A Common East Asian-Specific ALDH2 Mutation Causes Obesity and Insulin Resistance: Therapeutic Effect of Reducing Toxic Aldehydes by ALDH2 Activation. https://doi.org/10.21203/rs.3.rs-104384/v1 Published: Chang, Y.-C., Lee, H.-L., Yang, W., Hsieh, M.-L., Liu, C.-C., Lee, T.-Y., Huang, J.-Y., Nong, J.-Y., Li, F.-A., Chuang, H.-L., Ding, Z.-Z., Su, W.-L., Chueh, L.-Y., Tsai, Y.-T., Chen, C.-H., Mochly-Rosen, D., & Chuang, L.-M. (2023). A Common East-Asian ALDH2 Mutation Causes Metabolic Disorders and the Therapeutic Effect of ALDH2 Activators. Nature Communications, 14(1), Article 1. https://doi.org/10.1038/s41467-023-41570-6 Guest info Matt Quinn https://twitter.com/Mqsley https://www.mquinn.online/ Biography: TL;DR Here's what I am working on: I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here I have failed at so so so many things - read about them here https://www.mquinn.online/ _______________________________________ Co-host Dr. Brian Kerley https://www.seedoilrebellion.com/ https://twitter.com/SeedOilDsrspctr Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/ Tucker Goodrich Substack: https://tuckergoodrich.substack.com/ Twitter: https://twitter.com/TuckerGoodrich Youtube: https://www.youtube.com/tuckergoodrich0 Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825 Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y Podcast: https://sites.libsyn.com/408758 Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/ _______________________________________ Show Notes Previous paper: Ghosh, S., Qi, D., An, D., Pulinilkunnil, T., Abrahani, A., Kuo, K.-H., Wambolt, R. B., Allard, M., Innis, S. M., & Rodrigues, B. (2004). Brief Episode of STZ-Induced Hyperglycemia Produces Cardiac Abnormalities in Rats Fed a Diet Rich in N-6 Pufa. American Journal of Physiology. Heart and Circulatory Physiology, 287(6), H2518-2527. https://doi.org/10.1152/ajpheart.00480.2004 Discussed in this episode: Ep. 12 Study: What's Worse—Carbs or Seed Oils? Understanding a High-PUFA Diet—with Dr. Brian Kerley and Matt Quinn https://tuckergoodrich.substack.com/p/ep-115-study-whats-worsecarbs-or HNE/4-HNE in Wikipedia https://en.wikipedia.org/wiki/4-Hydroxynonenal Gomes, K. M. S., Campos, J. C., Bechara, L. R. G., Queliconi, B., Lima, V. M., Disatnik, M.-H., Magno, P., Chen, C.-H., Brum, P. C., Kowaltowski, A. J., Mochly-Rosen, D., & Ferreira, J. C. B. (2014). Aldehyde Dehydrogenase 2 Activation in Heart Failure Restores Mitochondrial Function and Improves Ventricular Function and Remodelling. Cardiovascular Research, 103(4), 498–508. https://doi.org/10.1093/cvr/cvu125 If you have any questions about sources for things discussed please ask in the comments.

Introduction Brian and I are honored to be joined by the illustrious Chef Andrew Gruel. He tells us the story of how he got into cooking, how he had to learn to cook again after discovering that his academic chef training left out natural fats, and the impact using proper fats has had on his health, the health of his staff, and his customers in his latest restaurant venture. We also have an extensive and very interesting discussion on fish, fish farming, and the health benefits of eating fish. Guest info Web: www.chefgruel.com (It throws a security error…) X: https://twitter.com/ChefGruel Substack: “The Food Porn Master”! https://substack.com/@andrewgruel Instagram: https://www.instagram.com/andrewgruel/ Calico Fish House: https://calico-restaurant.com/ Biography: “Andrew Gruel, a graduate of Johnson & Wales University, is a food entrepreneur and television personality – he is the Founder of Slapfish Restaurant Group (27 locations), the award-winning food truck turned international brick and mortar, based out of Huntington Beach, CA and currently CEO and founder of American Gravy Restaurant Group which comprises Calico Fishhouse, Big Parm Pizza, Two Birds Chicken, Butterleaf, Lolo’s Tacos and 101 Burger. “Andrew has appeared on multiple television series including his most recent role as a judge on Food Network’s “Chopped Junior” with Megan Markle. He was the Host of FYI Series “Say It To My Face”, as well as a judge on Food Network’s “Food Truck Face Off.” He has made appearances on the TODAY show, Fox News, CNN, NBC Nightly News, PBS, Cooking Channel, and has been featured in numerous publications including The Wall Street Journal, Forbes, Men’s Health, Food & Wine magazine, USA Today, Entrepreneur and Nation’s Restaurant News. He was named Top 25 Business Executives for Fast Casual magazine as well as featured in Nation’s Restaurant News’ 2017 Power List. In 2013 he was named top 40 under 40 entrepreneurs in Orange County. He and his wife Lauren Gruel were named Pandemic Heroes by Restaurant Business Magazine alongside Guy Fieri and Jose Andres. He is currently the Co-Host of The SoCal Restaurant Show on AM 830 and a regular contributor on various national news channels.” http://www.chefgruel.com/index.php/about-us.html _______________________________________ Co-host Dr. Brian Kerley https://www.seedoilrebellion.com/ https://twitter.com/SeedOilDsrspctr Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/ Tucker Goodrich Substack: https://tuckergoodrich.substack.com/ Twitter: https://twitter.com/TuckerGoodrich Youtube: https://www.youtube.com/tuckergoodrich0 Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825 Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y Podcast: https://sites.libsyn.com/408758 Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/ _______________________________________ Show Notes Slapfish: https://www.slapfishrestaurant.com/ Nina Planck, “Real Food” https://amzn.to/3OhJBG8 Callico Fish House Restaurant: https://calico-restaurant.com/ Tom Brenna ep. 5: https://tuckergoodrich.substack.com/p/podcast-ep-5-prof-tom-brenna-on-omega Cargill & McDonalds: “Removing Trans Fats from McDonald’s® Famous Fries” https://www.cargill.com/history-story/en/HIGH-OLEIC.jsp “Podcast Ep. 0: What VICE Left Out: Bitcoin and Seed Oils—Starting a Podcast” https://yelling-stop.blogspot.com/2022/04/what-vice-left-out-bitcoin-and-seed.html If you have any questions about sources for things discussed please ask in the comments.

Introduction We’re trying something a bit different today. Dr. Brian Kerley and I have found a victim, Matt Quinn. Matt’s a smart guy but he’s not as immersed in these topics as we are, and so he’s going to play our straight man, the every-day guy who can hopefully come to easily-digested conclusions about the papers we discuss. In our inaugural episode we discuss “Brief Episode of STZ-Induced Hyperglycemia Produces Cardiac Abnormalities in Rats Fed a Diet Rich in N-6 PUFA”. Ghosh, S., Qi, D., An, D., Pulinilkunnil, T., Abrahani, A., Kuo, K.-H., Wambolt, R. B., Allard, M., Innis, S. M., & Rodrigues, B. (2004). Brief Episode of STZ-Induced Hyperglycemia Produces Cardiac Abnormalities in Rats Fed a Diet Rich in N-6 Pufa. American Journal of Physiology. Heart and Circulatory Physiology, 287(6), H2518-2527. https://doi.org/10.1152/ajpheart.00480.2004 Guest info Matt Quinn https://twitter.com/Mqsley https://www.mquinn.online/ Biography: TL;DR Here's what I am working on: I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here I have failed at so so so many things - read about them here https://www.mquinn.online/ _______________________________________ Co-host Dr. Brian Kerley https://www.seedoilrebellion.com/ https://twitter.com/SeedOilDsrspctr Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/ Tucker Goodrich Substack: https://tuckergoodrich.substack.com/ Twitter: https://twitter.com/TuckerGoodrich Youtube: https://www.youtube.com/tuckergoodrich0 Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825 Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y Podcast: https://sites.libsyn.com/408758 Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/ _______________________________________ Show Notes Ghosh, S., Qi, D., An, D., Pulinilkunnil, T., Abrahani, A., Kuo, K.-H., Wambolt, R. B., Allard, M., Innis, S. M., & Rodrigues, B. (2004). Brief Episode of STZ-Induced Hyperglycemia Produces Cardiac Abnormalities in Rats Fed a Diet Rich in N-6 Pufa. American Journal of Physiology. Heart and Circulatory Physiology, 287(6), H2518-2527. https://doi.org/10.1152/ajpheart.00480.2004 I discussed this in a blog post. I won’t be doing this for most of the studies we discuss, but I figured it was handy to start with one where I had already done some work! What's Worse—Carbs or Seed Oils? Understanding a High-PUFA Diet. tl;dr: The one study I'm aware of that shows conclusively that excess glucose acts as an accelerant for excess omega-6 fat, but it not nearly so harmful without the omega-6, in vivo. https://tuckergoodrich.substack.com/p/whats-worsecarbs-or-seed-oils-understanding If you have any questions about sources for things discussed please ask in the comments.

We interview Paul Saladino MD about his intellectual journey from being a raw vegan with rotting teeth as a physician’s assistant, through becoming the “Carnivore MD”, to where he is today. We discuss the training a physician receives in medical school about nutrition, and how he filled that gap with his own experience and research. And how it impacted his health and his ideas about being a physician. Josh Durham, my personal physician, joins me as co-host today to recount his personal health journey as well and how it changed his practice. (He recently quit his job at a large hospital to go independent!) Paul Saladino, MD: https://www.paulsaladinomd.co/ Dr. Saladino’s "The Carnivore Code" book: https://amzn.to/47OCjAt Biography of Paul Saladino: I’m a double board certified MD, host of the Fundamental Health podcast, and author of The Carnivore Code and The Carnivore Code Cookbook. I believe in questioning our assumptions about health and nutrition, which makes me controversial in modern medicine. I'm much more interested in optimal health than in dogmatic adherence to a mainstream narrative. I graduated from medical school at the University of Arizona in Tucson, and completed my residency at the University of Washington in Seattle. After residency, I attained a board certification as a Physician Nutrition Specialist. Throughout my medical training, I came to one very saddening conclusion: our Western medical system isn’t helping people lead richer lives. Western medicine fails to treat the root cause of chronic illness, and doctors are only taught to treat symptoms with medications, rather than trying to understand the roots of illness. I firmly believe that nutritional choices lie at the ROOT of so many chronic illnesses that western medicine deems irreversible. And I also believe that most chronic illnesses are preventable AND reversible. https://www.paulsaladinomd.co/about _______________________________________ Co-host Joshua Durham, DO: https://www.drdurham.org/ Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/ Tucker Goodrich Substack: https://tuckergoodrich.substack.com/ Twitter: https://twitter.com/TuckerGoodrich Youtube: https://www.youtube.com/tuckergoodrich0 Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825 Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y Podcast: https://sites.libsyn.com/408758 Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/ _______________________________________ Show Notes Jordan Petersen on Joe Rogan discussing carnivore diet: https://www.youtube.com/watch?v=HLF29w6YqXs Farley Mowat "People of the Deer" book: https://amzn.to/3Uc42bh Amgen: "8 Things to Know About Lipoprotein(a)" https://www.amgen.com/stories/2023/02/8-things-to-know-about-lipoproteina "AMGEN ANNOUNCES POSITIVE TOPLINE PHASE 2 DATA FOR INVESTIGATIONAL OLPASIRAN IN ADULTS WITH ELEVATED LIPOPROTEIN(a)": https://www.amgen.com/newsroom/press-releases/2022/05/amgen-announces-positive-topline-phase-2-data-for-investigational-olpasiran-in-adults-with-elevated-lipoproteina "Seed oils are BS" t-shirt: https://www.bunkerbranding.com/collections/paul-saladino-md-shirts/products/seed-oils-are-bs?variant=42776441782403 If you have any questions about sources for things discussed please ask in the comments.

Dr. Kerley and I are joined by Dalton Graham, a student who found himself in a liver pathology lab at Tulane. He had the interesting idea to test if a high-linoleic acid diet could be shown to produce fatty liver disease at the same time it was causing obesity. The scientists in the lab required a little convincing that this was a worthy experiment, but one day he arrived to find all the materials he need waiting for him. Be careful what you wish for! Find out how it turned out. Graham, D. S., Liu, G., Arasteh, A., Yin, X.-M., & Yan, S. (2023). Ability of High Fat Diet to Induce Liver Pathology Correlates with the Level of Linoleic Acid and Vitamin E in the Diet. PLOS ONE, 18(6), e0286726. https://doi.org/10.1371/journal.pone.0286726 Biography: • Dalton is currently a PhD student at University of Florida, studying Biochemistry with a focus on metabolism. When he wrote the paper we are discussing, he was an undergrad, and then grad student at Tulane University, studying Biochemical Engineering and Pathology. _______________________________________ Co-host Dr. Brian Kerley https://www.seedoilrebellion.com/ https://twitter.com/SeedOilDsrspctr Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/ Tucker Goodrich Substack: https://tuckergoodrich.substack.com/ Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/ Youtube: https://www.youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825 Podcast: https://sites.libsyn.com/408758 Twitter: https://twitter.com/TuckerGoodrich _______________________________________ Show Notes “Alvheim papers out of the NIH” Alvheim, A. R., Malde, M. K., Osei‐Hyiaman, D., Hong, Y. H., Pawlosky, R. J., Madsen, L., Kristiansen, K., Frøyland, L., & Hibbeln, J. R. (2012). Dietary Linoleic Acid Elevates Endogenous 2-AG and Anandamide and Induces Obesity. Obesity, 20(10), 1984–1994. https://doi.org/10.1038/oby.2012.38 Alvheim, A. R. (2012). Dietary linoleic acid induces obesity through excessive endocannabinoid activity [Doctor of Philosophy, The University of Bergen]. https://bora.uib.no/bora-xmlui/handle/1956/5962 NAFLD discovered in 1980: Ludwig, J., Viggiano, T. R., McGill, D. B., & Oh, B. J. (1980). Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clinic Proceedings, 55(7), 434–438. Liver transplants and NAFLD: Lindenmeyer, C. C., & McCullough, A. J. (2018). The Natural History of Nonalcoholic Fatty Liver Disease—An Evolving View. Clinics in Liver Disease, 22(1), 11. https://doi.org/10.1016/j.cld.2017.08.003 Linoleic acid and breast milk: Goodrich, T. D. (2022, September 1). Podcast Ep. 5: Prof. Tom Brenna on Omega-3 and Omega-6 in Human Health—with Dr Brian Kerley [Blog]. Yelling Stop. http://yelling-stop.blogspot.com/2022/09/podcast-ep-5-prof-tom-brenna-on-omega-3.html Gornoski, D. (2021, June 15). Bruce German on How Human Milk Does the Body Good (Jun 15 2021) [Mp3]. https://podcastaddict.com/episode/124448388 Speakman paper on lethargy: Speakman, J. R., De Jong, J. M. A., Sinha, S., Westerterp, K. R., Yamada, Y., Sagayama, H., Ainslie, P. N., Anderson, L. J., Arab, L., Bedu-Addo, K., Blanc, S., Bonomi, A. G., Bovet, P., Brage, S., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Cooper, J. A., Cooper, R., … Wong, W. W. (2023). Total Daily Energy Expenditure Has Declined Over the Past Three Decades Due to Declining Basal Expenditure, Not Reduced Activity Expenditure. Nature Metabolism, 5(4), 579–588. https://doi.org/10.1038/s42255-023-00782-2 Vitamin E: Masterjohn, C. (2017, June 24). 032: Is Coconut Oil Killing Us? [Substack newsletter]. Harnessing the Power of Nutrients. https://chrismasterjohnphd.substack.com/p/041-is-coconut-oil-killing-us Raghavamenon, A., Garelnabi, M., Babu, S., Aldrich, A., Litvinov, D., & Parthasarathy, S. (2009). α-Tocopherol Is Ineffective in Preventing the Decomposition of Preformed Lipid Peroxides and May Promote the Accumulation of Toxic Aldehydes: A Potential Explanation for the Failure of Antioxidants to Affect Human Atherosclerosis. Antioxidants & Redox Signaling, 11(6), 1237–1248. https://doi.org/10.1089/ars.2008.2248 NAFLD and Fructose: Vos, M. B., Weber, M. B., Welsh, J., Khatoon, F., Jones, D. P., Whitington, P. F., & McClain, C. J. (2009). Fructose and Oxidized LDL in Pediatric Nonalcoholic Fatty Liver Disease: A Pilot Study. Archives of Pediatrics & Adolescent Medicine, 163(7), 674–675. https://doi.org/10.1001/archpediatrics.2009.93 Cardiolipin: Goodrich, T. (2016, February 5). The Cause of Metabolic Syndrome: Excess Omega-6 Fats (Linoleic Acid) in Your Mitochondria. Yelling Stop. http://yelling-stop.blogspot.com/2016/02/the-cause-of-metabolic-syndrome-excess.html Quotable: “I made a presentation about the role of excess linoleic acid in liver diseases. …I sat down and I pitched it… to the individuals in that lab. At first they didn’t really get it… I remember when I first finished laying out the mechanisms and why this is needed. Typically at the end of a presentation there are a bunch of questions, and there was just… silence. “They’d never been presented with this idea that lipid peroxidation (or oxidative stress) manifests itself mainly due to this dietary factor—that no one seems to realize because it’s so ubiquitous.” “These animals that are eating the higher linoleic acid they appear physical slower.” “The females that were fed the high linoleic acid, they actually lost a lot of their fur [while under stress]. We couldn’t continue the experiment with them.” “I don’t think they understood the importance of [linoleic acid] in the real world.”

Dave Feldman and I discuss the what causes heart disease, specifically focusing on the consensus view and how it differs from what the science actually shows. Topics: Basic theory of CVD causation: • High ApoB/LDL/Cholesterol • Gradient causes penetration of arterial wall • Cholesterol/lipid oxidation in wall • Progression through stages of atherosclerosis • Blockage/rupture of plaque • Ischemia of blood to heart • Death/morbidity via MI Electro-negative LDL Aggregated LDL TG-rich Lipoproteins Risk and factor models FH mortality—implications for causality ApoB48 Albumin Vasa vasorum 'Atherosclerosis' in veins _______________________________________ Dave Feldman Biography: “I’m a senior software engineer and entrepreneur. “I began a Low Carb, High Fat diet in April 2015 and have since learned everything I could about it with special emphasis on cholesterol given my lipid numbers spiked substantially after going on the diet. As an engineer, I spotted a pattern in the lipid system that’s very similar to distributed objects in networks. “I’ve since learned quite a bit on the subject both through research and experimentation which has revealed some very powerful data. With this new general theory, I’ve shifted around my cholesterol substantially without any drugs or special supplements of any kind. From: https://cholesterolcode.com/about/ Blog: https://cholesterolcode.com/ Twitter: https://twitter.com/realDaveFeldman Citizen Science Foundation: Site: https://citizensciencefoundation.org/ Twitter: https://twitter.com/realCSF DONATE: https://citizensciencefoundation.org/donate/ Own Your Labs: https://ownyourlabs.com/ Tucker Goodrich Blog: http://yelling-stop.blogspot.com/ Substack: https://tuckergoodrich.substack.com/ Youtube: https://www.youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg Podcast: https://sites.libsyn.com/408758 Twitter: https://twitter.com/TuckerGoodrich Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/ _______________________________________ Show Notes Notes See the canine LMHR study: Kronfeld, D. S., Hammel, E. P., Ramberg, C. F., & Dunlap, H. L. (1977). Hematological and metabolic responses to training in racing sled dogs fed diets containing medium, low, or zero carbohydrate. The American Journal of Clinical Nutrition, 30(3), 419–430. https://doi.org/10.1093/ajcn/30.3.419 Lipid-Energy Model Norwitz, N. G., Feldman, D., Soto-Mota, A., Kalayjian, T., & Ludwig, D. S. (2022). Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a “Lean Mass Hyper-Responder” Phenotype. Current Developments in Nutrition, 6(1), nzab144. https://doi.org/10.1093/cdn/nzab144 Norwitz, N. G., Soto-Mota, A., Kaplan, B., Ludwig, D. S., Budoff, M., Kontush, A., & Feldman, D. (2022). The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets. Metabolites, 12(5), Article 5. https://doi.org/10.3390/metabo12050460 PubMed for Dave's other papers: https://pubmed.ncbi.nlm.nih.gov/?term=norwitz+feldman&sort=pubdate See Substack for full show notes—They don't fit here https://tuckergoodrich.substack.com/

Discussion with Paul Hart, formerly of Unilever and currently a consultant to the processed food industry, on the pros and cons are of processed foods, and what the food industry is hoping to accomplish.

Medicine needs to be fixed: “The New Crisis of Increasing All-Cause Mortality in US Children and Adolescents” • https://jamanetwork.com/journals/jama/article-abstract/2802602 Dr. Tro Kalayjian Dr. Tro’s Medical Weight Loss • https://doctortro.com/ Research: • https://scholar.google.com/citations?user=ByYma7sAAAAJ Twitter: • https://twitter.com/DoctorTro Dr. Brian Lenzkes Metabolic Health: • San Diego: https://sandiegometabolichealth.com/ • Arizona: https://arizonametabolichealth.com/brian-lenzkes-md/ Twitter: • https://twitter.com/BrianLenzkes Dr. Joshua Durham Twitter: • https://twitter.com/JoshuaD81699641 Dr. Eric Westman • https://ericwestmanmd.com/ New Atkins for a New You: The Ultimate Diet for Shedding Weight and Feeling Great by Eric C. Westman, Stephen D. Phinney, Jeff S. Volek • https://amzn.to/3qd9fzy (this link benefits the podcast!) Philip Ovadia • https://ovadiahearthealth.com/ Alessio Fassano • https://nutrition.hms.harvard.edu/people/alessio-fasano Research: • https://scholar.google.com/citations?user=8IxzUn0AAAAJ&hl=en&oi=ao Whole30 • https://whole30.com/ Virta • https://www.virtahealth.com/ Dr. Tro app • https://apps.apple.com/us/app/doctor-tro/id1588693888 Lenzkes & Kalayjian’s podcast: Low-Carb MD Podcast • https://www.lowcarbmd.com/ _______________________________________ Co-host Dr. Brian Kerley https://www.seedoilrebellion.com/ https://twitter.com/SeedOilDsrspctr Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/ Tucker Goodrich Blog: http://yelling-stop.blogspot.com/ Youtube: https://www.youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg Podcast: https://sites.libsyn.com/408758 Twitter: https://twitter.com/TuckerGoodrich _______________________________________

Dr. Durham is a Family Physician in Boise, Idaho; and is Tucker's doctor. We discuss how his practice has changed since he figured out how to solve his own chronic health problems, how this has changed his practice, some successes, and more. Joshua Durham, DO • https://www.saintalphonsus.org/provider/joshua-durham Blog comment: Dr. Durham: “If you need a family Dr. here in Boise hit me up. I went from 235lbs to keto to carnivore and then finally came across your info. Now at 195 I feel comfortable knowing what I can and can't have and why I was so sick. Felt great on carnivore but can't live that way forever. Thank you for your work.” • http://yelling-stop.blogspot.com/2021/04/experts-do-as-we-say-not-as-we-do.html?showComment=1620609617154#c416429453974276542 “Doctor of Osteopathy vs. Medical Doctor- What are the Differences?” • https://hecec.human.cornell.edu/2016/02/12/doctor-of-osteopathy-vs-medical-doctor-what-are-the-differences/ Dr. Eric Westman • https://ericwestmanmd.com/ New Atkins for a New You: The Ultimate Diet for Shedding Weight and Feeling Great by Eric C. Westman, Stephen D. Phinney, Jeff S. Volek • https://amzn.to/3qd9fzy (this link benefits the podcast!) Dr. Durham: “Good fat/bad fat” I wrote a post about this: “Good Keto vs. Bad Keto” • http://yelling-stop.blogspot.com/2021/09/good-keto-vs-bad-keto.html Dr. Durham: “Then I saw your interview with Paul Saladino…” • “How Seed Oils Destroy Your Mitochondria and Lead To Chronic Disease, with Tucker Goodrich” https://carnivoremd.com/how-seed-oils-destroy-your-mitochondria-and-lead-to-chronic-disease-with-tucker-goodrich/ “…and then I watched Brad Marshall…” • Brad’s blog is here: https://fireinabottle.net/ Drs. Kerley and Durham compare “elevator pitches” to patients. Dr. Durham: “I needed 4 pills based on the guidelines, and I was 38 years old.” Tucker: “Lean-Mass Hyper Responder”: Norwitz, N. G., Soto-Mota, A., Kaplan, B., Ludwig, D. S., Budoff, M., Kontush, A., & Feldman, D. (2022). The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets. Metabolites, 12(5), 460. https://doi.org/10.3390/metabo12050460 Dr. Durham: 40:02 “American College of Cardiology article…” Astrup, A., Magkos, F., Bier, D. M., Brenna, J. T., de Oliveira Otto, M. C., Hill, J. O., King, J. C., Mente, A., Ordovas, J. M., Volek, J. S., Yusuf, S., & Krauss, R. M. (2020). Saturated Fats and Health: A Reassessment and Proposal for Food-based Recommendations: JACC State-of -the-Art Review. Journal of the American College of Cardiology, 76(7), 844–857. https://doi.org/10.1016/j.jacc.2020.05.077 See Episode 5, in which we interview Tom Brenna, one of the co-authors of that article: https://www.youtube.com/watch?v=rrQ8q_ctGUQ Tucker: “The AGEs, same thing—Chris Masterjohn did a great post years ago looking into it: Masterjohn, C. (2011, October 7). Where Do Most AGEs Come From? O Glycation, How Thy Name Hast Deceived Me! | [Blog]. Chris Masterjohn, PhD. https://chrismasterjohnphd.com/blog/2011/10/07/where-do-most-ages-come-from-o Tucker: “Polyunsaturated fats are about 10x as effective in producing advanced glycation end products [than glucose]…” Fu, M.-X., Requena, J. R., Jenkins, A. J., Lyons, T. J., Baynes, J. W., & Thorpe, S. R. (1996). The Advanced Glycation End Product, N-(Carboxymethyl)lysine, Is a Product of both Lipid Peroxidation and Glycoxidation Reactions. Journal of Biological Chemistry, 271(17), 9982–9986. https://doi.org/10.1074/jbc.271.17.9982 Tucker: Lp(a): • Hazard ratio 16.8: Tsimikas, S., Brilakis, E. S., Miller, E. R., McConnell, J. P., Lennon, R. J., Kornman, K. S., Witztum, J. L., & Berger, P. B. (2005). Oxidized Phospholipids, Lp(a) Lipoprotein, and Coronary Artery Disease. New England Journal of Medicine, 353(1), 46–57. https://doi.org/10.1056/NEJMoa043175 • Hazard ratio 1 in Africa: Paré, G., Çaku, A., McQueen, M., Anand, S. S., Enas, E., Clarke, R., Boffa, M. B., Koschinsky, M., Wang, X., Yusuf, S., & null, null. (2019). Lipoprotein(a) Levels and the Risk of Myocardial Infarction Among 7 Ethnic Groups. Circulation, 139(12), 1472–1482. https://doi.org/10.1161/CIRCULATIONAHA.118.034311 • 2 sure-fire ways to raise Lp(a): 1. Statins: Yeang, C., Hung, M.-Y., Byun, Y.-S., Clopton, P., Yang, X., Witztum, J. L., & Tsimikas, S. (2016). Effect of therapeutic interventions on oxidized phospholipids on apolipoprotein B100 and lipoprotein(a). Journal of Clinical Lipidology, 10(3), 594–603. https://doi.org/10.1016/j.jacl.2016.01.005 2. Healthy diet: Navab Mohamad, Reddy Srinivasa T., Van Lenten Brian J., & Fogelman Alan M. (2004). Apparent Paradox of Low-Fat “Healthy” Diets Increasing Plasma Levels of Oxidized Low-Density Lipoprotein and Lipoprotein(a). Arteriosclerosis, Thrombosis, and Vascular Biology, 24(3), 392–393. https://doi.org/10.1161/01.ATV.0000118014.49565.fc • Pork and LDL: Stewart, J. W., Kaplan, M. L., & Beitz, D. C. (2001). Pork with a high content of polyunsaturated fatty acids lowers LDL cholesterol in women. The American Journal of Clinical Nutrition, 74(2), 179–187. https://doi.org/10.1093/ajcn/74.2.179 Treating Lp(a)/OxLDL with antibodies: https://www.oxitopepharma.com/approach Dr. Kerley: Robb Wolf interview: https://www.youtube.com/watch?v=Lku8kJdHOqY Wooden breast in chickens: Soglia, F., Mudalal, S., Babini, E., Di Nunzio, M., Mazzoni, M., Sirri, F., Cavani, C., & Petracci, M. (2016). Histology, composition, and quality traits of chicken Pectoralis major muscle affected by wooden breast abnormality. Poultry Science, 95(3), 651–659. https://doi.org/10.3382/ps/pev353 “Dr. Mark Cucuzzella – A Doctor’s Perspective On Treating Diabetes” https://robbwolf.com/2016/07/26/episode-329-dr-mark-cucuzzella-a-doctors-perspective-on-treating-diabetes/

Human results of a low-linoleic diet with adequate omega-3 on neurodevelopment. The WHO change their guidelines to favor a low-linoleic diet for starving children How to protect against blindness. Why the Dietary Guidelines can’t get it right, and where they do. Fish vs fish oil for omega-3 DHA benefits. Fish consumption and mercury, is it a problem? Farmed vs. wild-caught fish. On the essentiality of linoleic acid. Linoleic acid impairs fertility Biography: Tom Brenna, Ph.D., Professor, Department of Pediatrics, Dell Medical School, UT Austin; • https://dellmed.utexas.edu/directory/tom-brenna “Tom Brenna is a professor of pediatrics at Dell Medical School. He moved to Austin after 28 years as a professor of human nutrition, chemistry, chemical biology and food science at Cornell University in Ithaca, New York. His group’s basic research into the chemical, biochemical, metabolic, genetic and ecological aspects of fatty acids have had a decisive influence on modern knowledge of these key nutrients. “Brenna’s research couples nutrition and chemistry in a broadly interdisciplinary program. His research group has been funded by institutes and centers at the National Institutes of Health (National Institute of General Medical Sciences, National Eye Institute, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Center for Complementary and Integrative Health) since 1992. Most of the work of the Brenna Lab is translational, tying basic research to biomedicine and human nutrition….” Professor Emeritus, Division of Nutritional Sciences, Cornell University. • https://www.human.cornell.edu/people/jtb4 _______________________________________ Co-host Dr. Brian Kerley https://www.seedoilrebellion.com/ https://twitter.com/SeedOilDsrspctr Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/ Tucker Goodrich Blog: http://yelling-stop.blogspot.com/ Youtube: https://www.youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg Podcast: https://sites.libsyn.com/408758 Twitter: https://twitter.com/TuckerGoodrich _______________________________________ Show notes For full show notes see my blog. (They won't fit here!)

**Credit where it's due: YouTube reinstated this video. https://twitter.com/raphaels7/status/1551790044574359555?s=20&t=bW6MvpGccWo-Lq1yaOj2Xw Banned from Youtube, where it was on Raphi's channel (https://www.youtube.com/user/ibragenio). ____________________________ Raphi: @1:12:55: "Hopefully one of the social media platforms will stay suffienty free and friendly to free speech so that we can keep discussing those things because that's where I learned about them. So if only we can keep doing that we've got some hope. If they don't censor us on that as well, because we get censored a lot about COVID on Youtube and elsewhere." ____________________________ "What is misinformation?" "Disagreement with authority" "Oh, well I guess that makes sense. History has shown authority is rarely wrong" https://twitter.com/HighDensityLife/status/1551601997773774849