healthcareTech

Talk on "Comments on the Digital Watermaking and DNA encryption" with Arch. Fr. Paisios Papadopoulos and Associate Professor Dr. Ioannis Kypraios (AI for Healthcare and Translational Medicine), UK on 04.12.21.

Talk on "Critical Thought and Research" with Arch. Fr. Paisios Papadopoulos and Associate Professor Dr. Ioannis Kypraios (AI for Healthcare and Translational Medicine), UK on 27.11.21.

Talk on "Digital DNA watermarking and gene encryption using the mRNA/mDNA injectables" with Arch. Fr. Paisios Papadopoulos and Associate Professor Dr. Ioannis Kypraios (AI for Healthcare and Translational Medicine), UK on 23.11.21.

Talk on "mRNA/mDNA injectables, misinformation and disinformation" with Arch. Fr. Paisios Papadopoulos and Associate Professor Dr. Ioannis Kypraios (AI for Healthcare and Translational Medicine), UK on 18.11.21.

Talk on "Magnetic Nanoparticles and mRNA/mDNA injectables" with Arch. Fr. Paisios Papadopoulos and Associate Professor Dr. Ioannis Kypraios (AI for Healthcare and Translational Medicine), UK on 13.11.21. REFERENCES Superconductors: [1] Superconductors, [Online] 13th November 2021. Available at: http://www.superconductors.org/ Superconducting Nanomaterials: [1] Shi, D., Guo, Z., Bedford, N., Superconducting Nanomaterials. Ed. Book "Nanomaterials and Devices", 2015. [2] Miranda, G. M., What is a Nanosuperconductor? (11th April 2019). AZO Nano [Online] 16th November 2021. Available at: https://www.azonano.com/article.aspx?ArticleID=5184 Nanoparticles and Superconductors: [1] Demming, A., Superconductivity-pairing up with nanotechnology (28 Feb 2018). Physics World, Feature: Nanomaterials [Online] 13th November 2021. Available at: https://physicsworld.com/a/superconductivity-pairing-up-with-nanotechnology/ [2] Keiji, E., Tsujita, Y., Nakamura, K., Sasayama, T., Yoshida, T. Biosensing utilizing magnetic markers and superconducting quantum interference devices. Superconductor Science and Technology, Vol. 30, No.5, 2017. [3] Sukmas, W., Tsuppayakorn-aek, P., Pinsook, U., Pinsook, U., Bovornratanaraks, T., Near-room-temperature superconductivity of Mg/Ca substituted metal hexahydride under pressure. J. of Alloys and Compounds, Vol.849, 2020. [4] Somayazulu, M., Ahart, M., Mishra, A. K., Geballe, Z. M., Baldini, M., Meng, Y., Struzhkin, V. V., Hemley, R. J., Evidence for Superconductivity above 260 K in Lanthanum Superhydride at Megabar Pressures. Phys. Rev. Lett., Vol.122, Issue 2, 2019. Magnetic Nanoparticles: [1] Buzea, C., Pacheco, I. Nanomaterial and Nanoparticle: Origin and Activity. Springer, Eds. Ghorbanpour M., Manika K., Varma A. "Nanoscience and Plant–Soil Systems." Vol 48. pp.71-112, 2017. [2] Shen, J., Hu, Y., Shi, M., Li, N., Ma, H., Ye, M. One Step Synthesis of Graphene Oxide−Magnetic Nanoparticle Composite. J. Phys. Chem. C Vol.114, No.3, pp.1498–1503, 2010. [3] Albert, E.L., Sajiman, M.B., Che Abdullah, C.A. Incorporation of magnetic nanoparticle to graphene oxide via simple emulsion method and their cytotoxicity. Appl Nanosci Vol.9, pp.43–48, 2019. [4] Koh, I., Josephson, L., Magnetic Nanoparticle Sensors. Sensors, Vol.9, pp.8130-8145, 2009. Magnetic Biosensors: [1] Bi, S., Cui, Y., Dong, Y., Zhang, N. Target-induced self-assembly of DNA nanomachine on magnetic particle for multi-amplified biosensing of nucleic acid, protein, and cancer cell. Biosensors and Bioelectronics, Vol.53, pp.207-213, 2014. [2] Llandro, J., Palfreyman, J.J., Ionescu, A., Barnes, C. H. W. Magnetic biosensor technologies for medical applications: a review. Med Biol Eng Comput Vol.48, pp.977–998, 2010.

Talk with Arch. Fr. Paisios Papadopoulos and Associate Professor Dr. Ioannis Kypraios (AI for Healthcare and Translational Medicine), UK on 11.11.21. Biosensors -Introduction: [1] Bhalla, N., Jolly, P., Formisano, N., & Estrela, P. Introduction to biosensors. Essays in biochemistry, Vol.60(1), pp.1–8, 2016. [2] Mehrotra, P. Biosensors and their applications - A review. Journal of oral biology and craniofacial research, Vol.6(2), pp.153–159, 2016. [3] Haleem, A., Javaid, M., Singh, R. P., Suman,R., Rab, S. Biosensors applications in medical field: A brief review. Sensors International, Vol.2(100100), 2021. Self-Powered Biosensors: [1] Grattieri, M., Minteer, S. D., Self-Powered Biosensors. ACS Sens. Vol.3, Issue 1, pp.44-53, 2018. [2] Zhang, S., Cicoira, F., Flexible self-powered biosensors. Nature, Vol.561, pp.466-467, 2018. [3] Roy, B. G., Rutherford, J. L., Weaver A. E., Beaver, K., Rasmussen, M. A Self-Powered Biosensor for the Detection of Glutathione. Biosensors. Vol.10(9):114, 2020. Implantable Biosensors: [1] Gray M., Meehan J., Ward C., Langdon S. P., Kunkler I. H., Murray A., Argyle D. Implantable biosensors and their contribution to the future of precision medicine. Vet J., Vol.239:21-29, 2018. [2] Scholten, K., Meng, E. A review of implantable biosensors for closed-loop glucose control and other drug delivery applications. Int J Pharm. Vol.544(2), pp.319-334, 2018. Magnetic Biosensors: [1] Haizhou, H., Shi, S., Nan, W., Hao, W., Shu, W., Hengchang, B., Litao, S., Graphene-Based Sensors for Human Health Monitoring. Frontiers in Chemistry, Vol.7, pp.399, 2019. [2] Medhi, R., Srinoi, P., Liu, T., Tran, H.-V., Marquez, M. D., Lee, T. R., Synthesis of Magnetic Nanoparticles for Biosensing, Material Matters, 14.4, 2020. Biosensors and Frequencies: [1] Afroz, S., Thomas, S. W., Mumcu, G., and Saddow, S. E. Implantable SiC based RF antenna biosensor for continuous glucose monitoring. Proc. of IEEE Sensors, pp.1-4, 2013. [2] Mehrotra, P., Chatterjee, B., & Sen, S. EM-Wave Biosensors: A Review of RF, Microwave, mm-Wave and Optical Sensing. Sensors (Basel, Switzerland), Vol.19(5), pp.1013, 2019. Protein Scaffolding: [1] Toyama, B. H., Savas, J. N., Park, S. K., Harris, M. S., Ingolia, N. T., Yates, J. R., 3rd, & Hetzer, M. W. Identification of long-lived proteins reveals exceptional stability of essential cellular structures. Cell, Vol.154, No.5, pp.971–982, 2020. AI and Biosensors: [1] Xiaofeng, J., Liu, C., Xu, T., Su, L., Zhang, X. Artificial intelligence biosensors: Challenges and prospects. Biosensors and Bioelectronics, Vol.165, 2020.

Talk with Arch. Fr. Paisios Papadopoulos and Associate Professor Dr. Ioannis Kypraios (AI for Healthcare and Translational Medicine), UK on 06.11.21. UK Gov Emergency Authorisation of Vaccines: [1] BioNTech SE, A Trial Investigating the Safety and Effects of Four BNT162 Vaccines Against COVID-2019 in Healthy and Immunocompromised Adults. Clinical Trials. [Online] 06th November 2021. Available at: https://clinicaltrials.gov/ct2/show/NCT04380701 Synthetic Genome: [1] Wang, H., Li, X., Li, T., Zhang, S., Wang, L., Wu, X., & Liu, J. (2020). The genetic sequence, origin, and diagnosis of SARS-CoV-2. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, Vol.39, No.9, pp.1629–1635, 2020. [2] Yadav, T., Srivastava, N., Mishra, G., Dhama, K., Kumar, S., Puri, B., & Saxena, S. K. Recombinant vaccines for COVID-19. Human vaccines & immunotherapeutics, Vol.16, No.12, pp.2905–2912, 2020. [3] Special Report, Garde, D., Saltzman, J., (10th November 2020). "The story of mRNA: How a once-dismissed idea became a leading technology in the Covid vaccine race.", [Online] 06th November 2021. Available at: https://www.statnews.com/2020/11/10/the-story-of-mrna-how-a-once-dismissed-idea-became-a-leading-technology-in-the-covid-vaccine-race/ Gene Transcription and Reverse Transcription: [1] Clancy, S. & Brown, W. Translation: DNA to mRNA to Protein. Nature Education, Vol.1(1):101, 2008. [2] Pray, L. The Biotechnology Revolution: PCR and the Use of Reverse Transcriptase to Clone Expressed Genes. Nature Education Vol.1(1):94, 2008. [3] Zhang, L., Richards, A., Barrasa, M. I., Hughes, S. H., Young, R. A., Jaenisch, R., Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues. Proc. of the Nat Acad Sci, Vol.118, No.21, 2021. Nanolipids: [1] Negi, J. S. "Chapter 6 - Nanolipid Materials for Drug Delivery Systems: A Comprehensive Review." Elsevier, Ed(s): Shyam S. Mohapatra, Shivendu Ranjan, Nandita Dasgupta, Raghvendra Kumar Mishra, Sabu Thomas, In Micro and Nano Technologies, Characterization and Biology of Nanomaterials for Drug Delivery, pp.137-163, 2019. [2] Nandwana, V., Singh, A., You, M. M., Zhang, G., Higham, J., Zheng, T.S., Li, Y., Prasadd, P. V., Dravid, V.P. Magnetic lipid nanocapsules (MLNCs): self-assembled lipid-based nanoconstruct for non-invasive theranostic applications. J. Mater. Chem. B, Vol.6, pp.1026-1034, 2018. Magnetic Nanoparticles: [1] Trafton, A., (26th April 2019). Nanoparticles take a fantastic, magnetic voyage Tiny robots powered by magnetic fields could help drug-delivery nanoparticles reach their targets. [Online] 6th November 2021. Available at: https://news.mit.edu/2019/nanoparticles-magnetic-robots-0426 [2] Kim,E., Jeon, S., An, H.-K., Kianpour, M., Yu, S.-W., Kim, J-Y., Rah, J.-C., Choi, H. A magnetically actuated microrobot for targeted neural cell delivery and selective connection of neural networks. Science Advances, Vol.6, No.39, 2020. Digital Watermarking for Synthetic Genome: [1] Clelland, C., Risca, V. & Bancroft, C. Hiding messages in DNA microdots. Nature, Vol.399, pp.533–534, 1999. [2] Heider, D., Barnekow, A. DNA watermarks: A proof of concept. BMC Molecular Biol, Vol.9, No.40, 2008. [3] Liss M, Daubert D, Brunner K, Kliche K, Hammes U, Leiherer A, Wagner, R. Embedding Permanent Watermarks in Synthetic Genes. PLoS ONE, Vol.7(8): e42465, 2012. Protein Scaffolding: [1] Dokland, T. Scaffolding proteins and their role in viral assembly. Cell Mol Life Sci., Vol.56(7-8), pp.580-603, 1999. NHS/NICE Phychosomatic Effects: [1] Spillane A., Larkin C., Corcoran P., Matvienko-Sikar K., Riordan F., Arensman E. Physical and psychosomatic health outcomes in people bereaved by suicide compared to people bereaved by other modes of death: a systematic review. BMC Public Health. Vol.17(1):939, 2017. [2] Rundell, J., et al. (version 11). Traumatic Stress Disorders in Medically Ill Patients An Evidence-Based Medicine (EBM) Monograph for Psychosomatic Medicine Practice. The Guidelines and Evidence-Based Medicine Subcommittee of the Clinical Practice Committee, Academy of Psychosomatic Medicine (APM) and The European Association of Psychosomatic Medicine (EAPM), May 2013. Web URL: https://www.eapm.eu.com/wp-content/uploads/2018/06/PTSD_APM-EAPM-Monograph.pdf

Discussion with Arch. Fr. Paisios and Dr. Ioannis Kypraios about mRNA and mDNA healthcare technologies. REFERENCES: Electron and Optical Mircroscopy: [1] Ogawa, N., Hoshisashi, K., Sekiguchi, H., Ichiyanagi, K., Matsushita, Y., Hirohata, Y., Suzuki, S., Ishikawa A., Sasaki, Y. C., Tracking 3D Picometer-Scale Motions of Single Nanoparticles with High-Energy Electron Probes. Sci Rep Vol.3, Issue 2201, 2013. Web: https://www.nature.com/articles/srep02201#citeas [2] Dume, I., Microscopy moves to the picoscale (10 June 2004). [Online] 30th October 2021. Available: https://physicsworld.com/a/microscopy-moves-to-the-picoscale/ Hydrogels: [1] Wang, W., Narin, R., Zeng, H., "Chapter 10 - Hydrogels." Elsevier, Ed. R. Narain, Polymer Science and Nanotechnology, pp.203-244, 2020. [2] Zhao, H., Liu, C., Gu, Z., Dong, L., Li, F., Yao, C. and Yang, D., Persistent Luminescent Nanoparticles Containing Hydrogels for Targeted, Sustained, and Autofluorescence-Free Tumor Metastasis Imaging. Nano Letters, Vol.20, Issue 1, pp.252-260, 2020. Web: https://pubs.acs.org/doi/abs/10.1021/acs.nanolett.9b03755 Nanodots: [1] Yi, C., Pan, Y., Fang, Y., "Chapter 5 - Surface Engineering of Carbon Nanodots (C-Dots) for Biomedical Applications." Elsevier, Ed. X. Wang & X. Chen, In Micro and Nano Technologies, Novel Nanomaterials for Biomedical, Environmental and Energy Applications, pp.137-188, 2019. [2] GEN-Genetic Engineering & Biotechnology News, Quantum Dots Deliver Vaccines and Invisibly Encode Vaccination History in Skin (19th Dec. 2019). [Online] 30th October 2021. Available: https://www.genengnews.com/topics/drug-discovery/quantum-dots-deliver-vaccines-and-invisibly-encode-vaccination-history-in-skin/ Luciferase: [1] Creative Enzymes, Products - Enzymes for Research, Diagnostic amd Industrial Use: Luciferase. [Online] 30th October 2021. Available: https://www.creative-enzymes.com/similar/luciferase_418.html?msclkid=7212943ab4101573dd14f54051726596 [2] Botella, E., Noone, D., Salzberg, L. I., Hokamp, K., Krogh, S., Fogg, M., Wilkinson, A. J., Devine, K. M. "Chapter 1 - High-resolution temporal analysis of global promoter activity in Bacillus subtilis.", Academic Press, Ed. C. Harwood, A. Wipat, Methods in Microbiology, Vol.39, pp.1-26, 2012. [3] Omokoko, T. A., Luxemburger, U., Bardissi, S., Simon, P., Utsch, M., Breitkreuz, A., Türeci, O., Sahin, U., Luciferase mRNA Transfection of Antigen Presenting Cells Permits Sensitive Non-radioactive Measurement of Cellular and Humoral Cytotoxicity. J. of Immunology Res., Vol. 2016, Article ID 9540975, 2016. Web: https://www.hindawi.com/journals/jir/2016/9540975/

The truth about the injectables. Discussion with Arch. Fr. Paisios Papadopoulos, Nicholas Rigakis and Dr. Ioannis Kypraios, Associate Professor in AI for Healthcare Technologies and Translational Medicine.